EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.21 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | coptisine | 53.85-61.54% inhibition at 0.075 mg/ml | Homo sapiens | |
1.1.1.21 | coptisine | 85.86-86.87% inhibition at 0.05 mg/ml | Rattus norvegicus | |
1.1.1.21 | epiberberine | 69.23-76.92% inhibition at 0.075 mg/ml | Homo sapiens | |
1.1.1.21 | epiberberine | complete inhibition at 0.05 mg/ml | Rattus norvegicus | |
1.1.1.21 | groenlandicine | 69.23-76.92% inhibition at 0.075 mg/ml | Homo sapiens | |
1.1.1.21 | groenlandicine | 52.38-60.32% inhibition at 0.05 mg/ml | Rattus norvegicus | |
1.1.1.21 | jateorrhizine | 12.68-14.08% inhibition at 0.05 mg/ml | Rattus norvegicus | |
1.1.1.21 | magnoflorine | 18.33-29.85% inhibition at 0.05 mg/ml | Rattus norvegicus | |
1.1.1.21 | additional information | berberine and palmatine exhibit no RLAR inhibitory activities within the test concentration of 0.012.5-0.05 mg/ml; extract and fractions of the rhizome of Coptis chinensis exhibit broad and moderate RLAR inhibitory activities of approximately 0.038.9-0.067.5 mg/ml | Rattus norvegicus | |
1.1.1.21 | quercetin | - |
Homo sapiens | |
1.1.1.21 | quercetin | 76.47-77.94% inhibition at 0.005 mg/ml | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.21 | Homo sapiens | - |
- |
- |
1.1.1.21 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.21 | lens | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
1.1.1.21 | DL-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.21 | aldose reductase | - |
Homo sapiens |
1.1.1.21 | aldose reductase | - |
Rattus norvegicus |
1.1.1.21 | HRAR | - |
Homo sapiens |
1.1.1.21 | RLAR | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.21 | NADPH | - |
Homo sapiens | |
1.1.1.21 | NADPH | - |
Rattus norvegicus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.21 | 0.0188 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | quercetin | |
1.1.1.21 | 0.1 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | epiberberine | |
1.1.1.21 | 0.1184 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | coptisine | |
1.1.1.21 | 0.1401 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Rattus norvegicus | groenlandicine | |
1.1.1.21 | 0.1542 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | groenlandicine | |
1.1.1.21 | 0.1681 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | epiberberine | |
1.1.1.21 | 0.1873 | - |
in 100 mM sodium phosphate buffer (pH 6.2) | Homo sapiens | coptisine |