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Literature summary extracted from

  • Wierzchowski, J.; Pietrzak, M.; Szelag, M.; Wroczynski, P.
    Salivary aldehyde dehydrogenase-Reversible oxidation of the enzyme and its inhibition by caffeine, investigated using fluorimetric method (2008), Arch. Oral Biol., 53, 423-428.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Caffeine
-
 Homo sapiens
1.2.1.3 theophylline
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.00024
-
 2-naphthalene carboxylate apparent Km value, diphosphate buffer, pH 8.1, cofactor NADH Homo sapiens
1.2.1.3 0.0012
-
 NAD+ apparent Km value Homo sapiens
1.2.1.3 0.0017
-
 6-dimethylamino-2-naphthaldehyde apparent Km value, pyrophosphate buffer, pH 8.1, cofactor NAD+ Homo sapiens
1.2.1.3 0.0079
-
 6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 7.3, cofactor NAD+ Homo sapiens
1.2.1.3 0.0086
-
 6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 6.2, cofactor NAD+ Homo sapiens
1.2.1.3 0.0114
-
 6-dimethylamino-2-naphthaldehyde apparent Km value, phosphate buffer, pH 8.0, cofactor NAD+ Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 additional information Homo sapiens involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 saliva
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 2-naphthaldehyde + NAD+ + H2O
-
 Homo sapiens 2-naphthalene carboxylate + NADH + H+
-
 ?
1.2.1.3 6-dimethylamino-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-dimethylamino-2-naphthalene carboxylate + NADH + H+
-
 ?
1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-methoxy-2-naphthalene carboxylate + NADH + H+
-
 ?
1.2.1.3 additional information involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.3 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase
-
 Homo sapiens
1.2.1.3 ALDH
-
 Homo sapiens
1.2.1.3 ALDH3A1
-
 Homo sapiens
1.2.1.3 benzaldehyde dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.3 25
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens
1.2.1.3 NADP+
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.3 3.5
-
 Caffeine apparent Ki value Homo sapiens
1.2.1.3 7.3
-
 theophylline apparent Ki value Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.3 2.5
-
-
 Homo sapiens Caffeine
1.2.1.3 3.5
-
-
 Homo sapiens theophylline