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Literature summary extracted from

  • Subbaiah, P.V.; Sowa, J.M.; Singh, D.K.
    Sphingolipids and cellular cholesterol homeostasis. Effect of ceramide on cholesterol trafficking and HMG CoA reductase activity (2008), Arch. Biochem. Biophys., 474, 32-38.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.34 additional information phosphorylation of HMGCR is stimulated by SMase C or exogenous ceramide Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.34 ceramide treatment with exogenous ceramides, or increasing the endogenous ceramide levels inhibits HMGCR by 60–80% Homo sapiens
1.1.1.34 SMase C treatment of fibroblasts with SMase C results in a 90% inhibition of HMGCR Homo sapiens
1.1.1.34 SMase D treatment of fibroblasts with SMase D inhibits by 29% Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.34 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 mevaldehyde + NADPH + H+
-
 Homo sapiens (R)-mevalonate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 HMG CoA reductase
-
 Homo sapiens
1.1.1.34 HMGCR
-
 Homo sapiens