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Literature summary extracted from
- Brevibacillus sp: A novel thermophilic source for the production of bile salt hydrolase (2009), Appl. Biochem. Biotechnol., 157, 254-262.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.1.24 | medicine | using bile salt deconjugation to lower serum cholesterol levels in hypercholesteremic patients and prevent hypercholesteremia in normal people is of great interest | Brevibacillus sp. |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.24 | additional information | Brevibacillus sp. | catalyzes the hydrolysis of glycine- and taurine-conjugated bile salts to amino acid residues and free bile salts | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.24 | Brevibacillus sp. | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | additional information | - |
glycocholic acid 2.2 U, glycodeoxycholic acid 2.7 U, glycochenodeoxycholic acid 1.7 U, taurocholic acid 1.7 U, taurodeoxycholic acid 1.7 U, taurochenodeoxycholic acid 1.7 U | Brevibacillus sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.24 | glycochenodeoxycholic acid + H2O | - |
Brevibacillus sp. | 3alpha,7alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| 3.5.1.24 | glycocholic acid + H2O | - |
Brevibacillus sp. | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + Gly | - |
? | |
| 3.5.1.24 | glycodeoxycholic acid + H2O | - |
Brevibacillus sp. | 3alpha,12alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| 3.5.1.24 | additional information | catalyzes the hydrolysis of glycine- and taurine-conjugated bile salts to amino acid residues and free bile salts | Brevibacillus sp. | ? | - |
? | |
| 3.5.1.24 | taurochenodeoxycholic acid + H2O | - |
Brevibacillus sp. | chenodeoxycholate + taurine | - |
? | |
| 3.5.1.24 | taurocholic acid + H2O | - |
Brevibacillus sp. | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + taurine | - |
? | |
| 3.5.1.24 | taurodeoxycholic acid + H2O | - |
Brevibacillus sp. | 3alpha,12alpha-dihydroxy-5beta-cholanate + taurine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.24 | bile salt hydrolase | - |
Brevibacillus sp. |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 40 | - |
bile salt hydrolase assay | Brevibacillus sp. |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 40 | 65 | - |
Brevibacillus sp. |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 6.5 | - |
bile salt hydrolase assay | Brevibacillus sp. |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.24 | 6 | 9 | - |
Brevibacillus sp. |
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Release 2023.1 (January 2023)
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