Any feedback?
Literature summary extracted from
- The hydrogenases and formate dehydrogenases of Escherichia coli (1994), Antonie van Leeuwenhoek, 66, 57-88.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.98.4 | iodoacetamide | inhibition is enhanced in the presence of formate | Escherichia coli |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.17.98.4 | Fe | the enzyme may contain one 4Fe-4S cluster | Escherichia coli | |
| 1.17.98.4 | Mo | contains bis-molybdopterin guanine dinucleotide | Escherichia coli | |
| 1.17.98.4 | Se | selenocysteine is located at amino acid position 140 | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.98.4 | formate + HycB | Escherichia coli | the hydrogenase 3 Fe-S subunit HycB may represent the electron transfer partner of FDH-H | CO2 + reduced HycB | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.17.98.4 | Escherichia coli | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.17.98.4 | additional information | FDH-H synthesis is optimal when Escherichia coli grows fermentatively | Escherichia coli | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.17.98.4 | formate + benzyl viologen | FDH-H remains essentially unchanged when deuteroformate is used as a substrate | Escherichia coli | CO2 + reduced benzyl viologen | - |
? | |
| 1.17.98.4 | formate + HycB | the hydrogenase 3 Fe-S subunit HycB may represent the electron transfer partner of FDH-H | Escherichia coli | CO2 + reduced HycB | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.17.98.4 | More | hydrogenase 3 (Hyd-3) together with formate dehydrogenase H (FDH-H) forms part of the formate hydrogenlyase (FHL) complex | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.17.98.4 | Fdh-H | hydrogenase 3 (Hyd-3) together with formate dehydrogenase H (FDH-H) forms part of the formate hydrogenlyase (FHL) complex | Escherichia coli |
| 1.17.98.4 | formate hydrogenlyase | hydrogenase 3 (Hyd-3) together with formate dehydrogenase H (FDH-H) forms part of the formate hydrogenlyase (FHL) complex | Escherichia coli |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
