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Literature summary extracted from

  • Mendonca, N.; Manageiro, V.; Bonnet, R.; Canica, M.
    Biochemical characterization of SHV-55, an extended-spectrum class a beta -lactamase from Klebsiella pneumoniae (2008), Antimicrob. Agents Chemother., 52, 1897-1898.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanic acid
-
 Klebsiella pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.005
-
 penicillin G
-
 Klebsiella pneumoniae
3.5.2.6 0.005
-
 aztreonam
-
 Klebsiella pneumoniae
3.5.2.6 0.006
-
 ticarcillin
-
 Klebsiella pneumoniae
3.5.2.6 0.008
-
 piperacillin
-
 Klebsiella pneumoniae
3.5.2.6 0.009
-
 cephalothin
-
 Klebsiella pneumoniae
3.5.2.6 0.01
-
 amoxicillin
-
 Klebsiella pneumoniae
3.5.2.6 0.021
-
 cefotaxime
-
 Klebsiella pneumoniae
3.5.2.6 0.023
-
 cefuroxime
-
 Klebsiella pneumoniae
3.5.2.6 0.058
-
 ceftazidime
-
 Klebsiella pneumoniae
3.5.2.6 0.149
-
 cefepime
-
 Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Klebsiella pneumoniae Q4TVR4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 amoxicillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 aztreonam + H2O
-
 Klebsiella pneumoniae [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
3.5.2.6 cefepime + H2O
-
 Klebsiella pneumoniae (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefotaxime + H2O
-
 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 ceftazidime + H2O
-
 Klebsiella pneumoniae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefuroxime + H2O
-
 Klebsiella pneumoniae (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O
-
 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 penicillin G + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 piperacillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 beta-lactamase
-
 Klebsiella pneumoniae
3.5.2.6 SHV-55
-
 Klebsiella pneumoniae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 0.1
-
 aztreonam above Klebsiella pneumoniae
3.5.2.6 7
-
 cefuroxime
-
 Klebsiella pneumoniae
3.5.2.6 8
-
 ticarcillin
-
 Klebsiella pneumoniae
3.5.2.6 9
-
 ceftazidime
-
 Klebsiella pneumoniae
3.5.2.6 23
-
 penicillin G
-
 Klebsiella pneumoniae
3.5.2.6 23
-
 amoxicillin
-
 Klebsiella pneumoniae
3.5.2.6 24
-
 cefotaxime
-
 Klebsiella pneumoniae
3.5.2.6 27
-
 piperacillin
-
 Klebsiella pneumoniae
3.5.2.6 30
-
 cefepime
-
 Klebsiella pneumoniae
3.5.2.6 38
-
 cephalothin
-
 Klebsiella pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.2.6 0.00002
-
-
 Klebsiella pneumoniae clavulanic acid