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Literature summary extracted from

  • Macchiarulo, A.; Camaioni, E.; Nuti, R.; Pellicciari, R.
    Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease (2009), Amino Acids, 37, 219-229.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.52
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 1-methyl-L-tryptophan
-
 Homo sapiens
1.13.11.52 1-methyl-L-tryptophan
-
 Mus musculus
1.13.11.52 additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens
1.13.11.52 additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus
1.13.11.52 vitamin K3 menadione Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Homo sapiens P14902
-
-
1.13.11.52 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.13.11.52 L-tryptophan + O2 = N-formyl-L-kynurenine Criegee type rearrangement for ring opening Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-tryptophan + O2
-
 Mus musculus N-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Homo sapiens N-formylkynurenine
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 monomer
-
 Mus musculus
1.13.11.52 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 indoleamine 2,3-dioxygenase
-
 Mus musculus
1.13.11.52 indoleamine 2,3-dioxygenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme
-
 Mus musculus
1.13.11.52 heme
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 additional information
-
 additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus
1.13.11.52 additional information
-
 additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens
1.13.11.52 0.062
-
 1-methyl-L-tryptophan
-
 Homo sapiens
1.13.11.52 0.105
-
 1-methyl-L-tryptophan
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.52 additional information
-
 review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus additional information
1.13.11.52 additional information
-
 review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens additional information
1.13.11.52 0.001
-
-
 Homo sapiens vitamin K3