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Literature summary extracted from

  • Miyaki, A.; Yang, P.; Tai, H.H.; Subbaramaiah, K.; Dannenberg, A.J.
    Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes (2009), Am. J. Physiol. Gastrointest. Liver Physiol., 297, G559-G566.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 additional information bile acids activate the signal transduction pathway protein kinase C-> extracellular signal-regulated kinase 1/2-> early growth response factor-1-> Snail and thereby suppress 15-PGDH transcription, unconjugated bile acids are much more potent inhibitors of 15-PGDH expression and activity than related conjugated bile acids, chenodeoxycholate and deoxycholate suppress the transcription of 15-PGDH resulting in reduced amounts of mRNA, protein, and enzyme activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.141 colonic cancer cell
-
 Homo sapiens
-
1.1.1.141 colonocyte
-
 Homo sapiens
-
1.1.1.141 HCT-15 cell
-
 Homo sapiens
-
1.1.1.141 HT-29 cell
-
 Homo sapiens
-
1.1.1.141 SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 15-hydroxyprostaglandin + NAD+
-
 Homo sapiens 15-oxoprostaglandin + NADH + H+
-
 ?
1.1.1.141 prostaglandin E2 + NAD+
-
 Homo sapiens 15-ketoprostaglandin E2 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens
1.1.1.141 NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.141 NAD+ dependent on Homo sapiens