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Literature summary extracted from

  • Nivinskas, H.; Nemeikaite-Ceniene, A.; Maroziene, A.; Normantiene, T.; Cenas, N.
    Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase (2007), Z. Naturforsch. C, 61, 889-895.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 desferrioxamine stimulates the NADPH:chromate reductase reaction of NQO1 Rattus norvegicus

Application

EC Number Application Comment Organism
1.6.5.2 additional information oxidative stress-type cytotoxicity of chromate in FLK cells may be partly attributed to its reduction by NQO1, but not by glutathione reductase Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.2 dicumarol inhibits the reduction of chromate by the digiton-permeabilized FLK cells in the presence of NADPH regeneration system. Protects against cytotoxicity by inhibiting NQO1 Ovis aries
1.6.5.2 SOD inhibits the NADPH:chromate reductase reaction of NQO1 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Ovis aries
-
-
-
1.6.5.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 FLK cell
-
 Ovis aries
-
1.6.5.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 chromate(VI) + H2O
-
 Ovis aries chromate(III) + H2O2
-
 ?
1.6.5.2 chromate(VI) + H2O extremely poor substrate Rattus norvegicus chromate(III) + H2O2
-
 ?
1.6.5.2 menadione + NADPH
-
 Rattus norvegicus reduced menadione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 DT-diaphorase
-
 Rattus norvegicus
1.6.5.2 DT-diaphorase
-
 Ovis aries
1.6.5.2 EC 1.6.99.2 formerly Rattus norvegicus
1.6.5.2 EC 1.6.99.2 formerly Ovis aries
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Rattus norvegicus
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Ovis aries
1.6.5.2 NQO1
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Ovis aries

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.5.2 0.11
-
 menadione at pH 7.0 and 27°C Rattus norvegicus
1.6.5.2 1.8
-
 chromate(VI) at pH 7.0 and 27°C Rattus norvegicus