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Literature summary extracted from

  • Hosseini-Maaf, B.; Letts, J.A.; Persson, M.; Smart, E.; LePennec, P.; Hustinx, H.; Zhao, Z.; Palcic, M.M.; Evans, S.V.; Chester, M.A.; Olsson, M.L.
    Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase (2007), Transfusion, 47, 864-875.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.37 gene ABO, DNA and amino acid sequence determination and analysis of different allelic variants, blood group genotyping Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.37 wild-type and mutant enzymes, X-ray diffraction structure determination and analysis at 1.99 A resolution, modelling Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.37 A268T naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 A268T naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 D262N naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 D262N naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 F216I naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 F216I naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 I192T naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 I192T naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 M189V naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 M189V naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
2.4.1.37 additional information identification of naturally occruing polymorphisms in the ABO gene, phenotypes, overview Homo sapiens
2.4.1.37 additional information identification of naturally occurring polymorphisms in the ABO gene, phenotypes, overview Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.37 additional information
-
 additional information kinetics of wild-type and mutant enzymes Homo sapiens
2.4.1.37 0.027
-
 UDP-galactose wild-type enzyme Homo sapiens
2.4.1.37 0.042
-
 UDP-galactose mutant D262N Homo sapiens
2.4.1.37 0.052
-
 UDP-galactose mutant F216I Homo sapiens
2.4.1.37 0.222
-
 UDP-galactose mutant A268T Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.37 cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.37 UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R Homo sapiens
-
 UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.37 Homo sapiens A5X6H3 fragment; ABO gene
-
2.4.1.37 Homo sapiens A5X6H4 fragment; ABO gene
-
2.4.1.37 Homo sapiens A5X6H5 fragment; ABO gene
-
2.4.1.37 Homo sapiens A5X6H7 fragment; ABO gene
-
2.4.1.37 Homo sapiens A5X6H8 fragment; ABO gene
-
2.4.1.37 Homo sapiens Q6L638 fragment; ABO gene
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.37 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.37 UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R
-
 Homo sapiens UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.37 More three-dimensional structure molecular modeling of wild-type and mutant enzymes Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.37 blood group B glycosyltransferase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.1.37 0.039
-
 UDP-galactose mutant A268T Homo sapiens
2.4.1.37 2
-
 UDP-galactose mutant F216I Homo sapiens
2.4.1.37 2.5
-
 UDP-galactose mutant D262N Homo sapiens
2.4.1.37 5.1
-
 UDP-galactose wild-type enzyme Homo sapiens