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Literature summary extracted from

  • Nishiya, T.; Mori, K.; Hattori, C.; Kai, K.; Kataoka, H.; Masubuchi, N.; Jindo, T.; Manabe, S.
    The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats (2008), Toxicol. Appl. Pharmacol., 232, 280-291.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.2.3 additional information tienilic acid induces the glutathione synthetase and all enzymes of the glutathione biosynthesis pathway, oxidative stress response, and phase II drug metabolism as do oxidative and/or electrophilic stresses, e.g. caused by tienilic acid, regulatory effects, overview Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.3 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine Rattus norvegicus the enzyme catalyzes the last step in glutathione biosynthesis ADP + phosphate + glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.3 Rattus norvegicus P46413 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.3 liver expression level in presence or absence of tienilic acid, overview Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine
-
 Rattus norvegicus ADP + phosphate + glutathione
-
 ?
6.3.2.3 ATP + gamma-L-glutamyl-L-cysteine + glycine the enzyme catalyzes the last step in glutathione biosynthesis Rattus norvegicus ADP + phosphate + glutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.3 Glutathione synthetase
-
 Rattus norvegicus
6.3.2.3 GSS
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.3 ATP
-
 Rattus norvegicus