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Literature summary extracted from

  • Fischer, J.W.; Schroer, K.
    Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis (2007), Thromb. Haemost., 98, 287-295.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.212 interleukin-1beta
-
 Mammalia
2.4.1.212 PDGF-BB
-
 Mammalia
2.4.1.212 prostacyclin
-
 Mammalia
2.4.1.212 prostaglandin E2
-
 Mammalia
2.4.1.212 prostaglandin F2alpha
-
 Mammalia
2.4.1.212 prostaglandin I2
-
 Mammalia
2.4.1.212 TGFbeta1
-
 Mammalia
2.4.1.212 TNFalpha
-
 Mammalia

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.212
-
 Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.212 4-methylesculetin
-
 Mammalia
2.4.1.212 4-Methylumbelliferone
-
 Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.212 plasma membrane
-
 Mammalia 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.212 UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] Mammalia
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 ?
2.4.1.212 UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] Mammalia
-
 UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Mammalia
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 fibroblast
-
 Mammalia
-
2.4.1.212 leukocyte
-
 Mammalia
-
2.4.1.212 mesangial cell
-
 Mammalia
-
2.4.1.212 oocyte
-
 Mammalia
-
2.4.1.212 pericardial mesothelium
-
 Mammalia
-
2.4.1.212 renal glomerulus
-
 Mammalia
-
2.4.1.212 synoviocyte
-
 Mammalia
-
2.4.1.212 uterine cervix
-
 Mammalia
-
2.4.1.212 vascular smooth muscle cell
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.212 UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 Mammalia UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
 ?
2.4.1.212 UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 Mammalia UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 HAS
-
 Mammalia
2.4.1.212 hyaluronan synthase
-
 Mammalia