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Literature summary extracted from

  • Yang, G.; Wu, L.; Jiang, B.; Yang, W.; Qi, J.; Cao, K.; Meng, Q.; Mustafa, A.K.; Mu, W.; Zhang, S.; Snyder, S.H.; Wang, R.
    H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase (2008), Science, 322, 587-590.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.1 calcium-calmodulin catalytic activity of pure CSE is increased more than 2fold by calcium and calmodulin, but not by either substance alone Mus musculus

Application

EC Number Application Comment Organism
4.4.1.1 additional information H2S is a physiologic vasodilator and regulator of blood pressure Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.4.1.1 additional information CSE-/- mice and CSE-/+ mice, mice genetically deficient in this enzyme display marked hypertension, comparable to that of eNOS-/- mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 DL-propargylglycine elevates blood pressure Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.1 aorta
-
 Mus musculus
-
4.4.1.1 blood vessel predominantly localized to the endothelial layer of blood vessels Mus musculus
-
4.4.1.1 endothelial cell
-
 Mus musculus
-
4.4.1.1 heart
-
 Mus musculus
-
4.4.1.1 serum
-
 Mus musculus
-
4.4.1.1 vascular system
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 CSE
-
 Mus musculus
4.4.1.1 cystathionine gamma-lyase
-
 Mus musculus