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Literature summary extracted from

  • Pauluhn, A.; Ahmed, H.; Lorentzen, E.; Buchinger, S.; Schomburg, D.; Siebers, B.; Pohl, E.
    Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax (2008), Proteins, 72, 35-43.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.2.14 synthesis stereospecific formation of carbon-carbon bonds is one of the major interests in organic synthetic chemistry, aldolases are part of the most important group of asymmetric C-C-bonding enzymes Saccharolobus solfataricus
4.1.2.14 synthesis stereospecific formation of carbon-carbon bonds is one of the major interests in organic synthetic chemistry, aldolases are part of the most important group of asymmetric C-C-bonding enzymes Thermoproteus tenax

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.14 using the pET expression system Saccharolobus solfataricus
4.1.2.14 using the pET expression system Thermoproteus tenax
4.1.2.21 using the pET expression system Saccharolobus solfataricus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.2.14 the crystal structure of the apoprotein is determined to a resolution of 2.0 A, the structure of the protein covalently linked to pyruvate is determined to 2.2 A Thermoproteus tenax

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.2.14 33000
-
-
 Thermoproteus tenax

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.14 2-dehydro-3-deoxy-6-phospho-D-gluconate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.14 2-dehydro-3-deoxy-6-phospho-D-gluconate Thermoproteus tenax
-
 pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.14 2-dehydro-3-deoxy-D-galactonate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde
-
 ?
4.1.2.14 2-dehydro-3-deoxy-D-gluconate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde
-
 r
4.1.2.14 2-dehydro-3-deoxy-D-gluconate Thermoproteus tenax
-
 pyruvate + D-glyceraldehyde
-
 r
4.1.2.14 2-keto-3-deoxy-6-phosphogalactonate Saccharolobus solfataricus
-
 ?
-
 ?
4.1.2.21 2-dehydro-3-deoxy-6-phospho-D-gluconate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.21 2-dehydro-3-deoxy-D-galactonate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde
-
 ?
4.1.2.21 2-dehydro-3-deoxy-D-gluconate Saccharolobus solfataricus
-
 pyruvate + D-glyceraldehyde
-
 r
4.1.2.21 2-keto-3-deoxy-6-phosphogalactonate Saccharolobus solfataricus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.14 Saccharolobus solfataricus
-
-
-
4.1.2.14 Thermoproteus tenax Q704D1
-
-
4.1.2.21 Saccharolobus solfataricus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.2.14
-
 Saccharolobus solfataricus
4.1.2.14
-
 Thermoproteus tenax
4.1.2.21
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.14 2-dehydro-3-deoxy-6-phospho-D-gluconate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.14 2-dehydro-3-deoxy-6-phospho-D-gluconate
-
 Thermoproteus tenax pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.14 2-dehydro-3-deoxy-D-galactonate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde
-
 ?
4.1.2.14 2-dehydro-3-deoxy-D-gluconate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde
-
 r
4.1.2.14 2-dehydro-3-deoxy-D-gluconate
-
 Thermoproteus tenax pyruvate + D-glyceraldehyde
-
 r
4.1.2.14 2-keto-3-deoxy-6-phosphogalactonate
-
 Saccharolobus solfataricus ?
-
 ?
4.1.2.21 2-dehydro-3-deoxy-6-phospho-D-gluconate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde 3-phosphate
-
 r
4.1.2.21 2-dehydro-3-deoxy-D-galactonate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde
-
 ?
4.1.2.21 2-dehydro-3-deoxy-D-gluconate
-
 Saccharolobus solfataricus pyruvate + D-glyceraldehyde
-
 r
4.1.2.21 2-keto-3-deoxy-6-phosphogalactonate
-
 Saccharolobus solfataricus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.14 2-keto-3-deoxy-(6-phospho)-gluconate aldolase
-
 Saccharolobus solfataricus
4.1.2.14 2-keto-3-deoxy-(6-phospho)-gluconate aldolase
-
 Thermoproteus tenax
4.1.2.14 KD(P)G aldolase
-
 Saccharolobus solfataricus
4.1.2.14 KD(P)G aldolase
-
 Thermoproteus tenax
4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
-
 Saccharolobus solfataricus