Literature summary extracted from

Henkes, L.E.; Sullivan, B.T.; Lynch, M.P.; Kolesnick, R.; Arsenault, D.; Puder, M.; Davis, J.S.; Rueda, B.R.
Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo (2008), Proc. Natl. Acad. Sci. USA, 105, 7670-7675.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.12	tumor necrosis factor	there is a significant increase in ASMase activity after treatment of MVEC cells with tmor necrosis factor	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.12	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.4.12	MVEC cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.12	sphingomyelin + H2O	-	Mus musculus	N-acylsphingosine + choline phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.4.12	acid sphingomyelinase	-	Mus musculus
3.1.4.12	aSMase	-	Mus musculus

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Release 2023.1 (January 2023)