EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.164 | - |
Methanocaldococcus jannaschii |
2.9.1.2 | - |
Homo sapiens |
2.9.1.2 | - |
Methanococcus maripaludis |
2.9.1.2 | - |
Methanocaldococcus jannaschii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.164 | ATP + seryl-tRNASec | Methanocaldococcus jannaschii | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.7.1.164 | ATP + seryl-tRNASec | Methanocaldococcus jannaschii DSM 2661 | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | Methanococcus maripaludis | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | Methanocaldococcus jannaschii | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | Homo sapiens | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase | L-selenocysteinyl-tRNASec + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.164 | Methanocaldococcus jannaschii | Q58933 | - |
- |
2.7.1.164 | Methanocaldococcus jannaschii DSM 2661 | Q58933 | - |
- |
2.9.1.2 | Homo sapiens | Q9HD40 | - |
- |
2.9.1.2 | Methanocaldococcus jannaschii | Q58027 | - |
- |
2.9.1.2 | Methanococcus maripaludis | Q6LZM9 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.9.1.2 | recombinant enzyme | Homo sapiens |
2.9.1.2 | recombinant enzyme | Methanococcus maripaludis |
2.9.1.2 | recombinant enzyme | Methanocaldococcus jannaschii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.164 | ATP + L-seryl-tRNASec | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanocaldococcus jannaschii | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.7.1.164 | ATP + L-seryl-tRNASec | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanocaldococcus jannaschii DSM 2661 | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.7.1.164 | ATP + seryl-tRNASec | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanocaldococcus jannaschii | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.7.1.164 | ATP + seryl-tRNASec | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanocaldococcus jannaschii DSM 2661 | ADP + O-phospho-L-seryl-tRNASec | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | - |
Homo sapiens | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | - |
Methanococcus maripaludis | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | - |
Methanocaldococcus jannaschii | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanococcus maripaludis | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) | Methanocaldococcus jannaschii | L-selenocysteinyl-tRNASec + phosphate | - |
? | |
2.9.1.2 | O-phospho-L-seryl-tRNASec + selenophosphate | L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase | Homo sapiens | L-selenocysteinyl-tRNASec + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.164 | O-phosphoseryl-tRNASec kinase | - |
Methanocaldococcus jannaschii |
2.7.1.164 | PSTK | - |
Methanocaldococcus jannaschii |
2.9.1.2 | SepSecS | - |
Homo sapiens |
2.9.1.2 | SepSecS | - |
Methanococcus maripaludis |
2.9.1.2 | SepSecS | - |
Methanocaldococcus jannaschii |
2.9.1.2 | SLA/LP | - |
Homo sapiens |
2.9.1.2 | SLA/LP | - |
Methanococcus maripaludis |
2.9.1.2 | SLA/LP | - |
Methanocaldococcus jannaschii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.9.1.2 | pyridoxal 5'-phosphate | the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine | Homo sapiens | |
2.9.1.2 | pyridoxal 5'-phosphate | the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine | Methanococcus maripaludis | |
2.9.1.2 | pyridoxal 5'-phosphate | the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine | Methanocaldococcus jannaschii |