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Literature summary extracted from

  • Hou, W.; Li, Y.; Zhang, Q.; Wei, X.; Peng, A.; Chen, L.; Wei, Y.
    Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors (2008), Phytother. Res., 23, 614-618.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.1 acarbose
-
 Sus scrofa
3.2.1.1 corosolic acid triterpene acid isolated from Lagerstroemia speciosa leaves, weak inhibitory activity Sus scrofa
3.2.1.1 additional information no inhibition with voglibose, 23-hydroxyursolic acid, maslinic acid, asiatic acid, arjunolic acid, and oleanolic acid Sus scrofa
3.2.1.20 23-hydroxyursolic acid triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity Saccharomyces cerevisiae
3.2.1.20 arjunolic acid triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity Saccharomyces cerevisiae
3.2.1.20 asiatic acid triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity Saccharomyces cerevisiae
3.2.1.20 corosolic acid triterpene acid isolated from Lagerstroemia speciosa leaves, shows best bioactivity Saccharomyces cerevisiae
3.2.1.20 maslinic acid triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity Saccharomyces cerevisiae
3.2.1.20 additional information no inhibition with acarbose or voglibose Saccharomyces cerevisiae
3.2.1.20 oleanolic acid triterpene acid isolated from Lagerstroemia speciosa leaves, moderate inhibitory activity Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.1 Sus scrofa
-
-
-
3.2.1.20 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.1 pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.1 maltose + H2O
-
 Sus scrofa D-glucose + D-glucose
-
 ?
3.2.1.1 starch + H2O
-
 Sus scrofa ?
-
 ?
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Saccharomyces cerevisiae 4-nitrophenol + alpha-D-glucopyranose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.1 alpha-amylase
-
 Sus scrofa
3.2.1.20 alpha-glucosidase
-
 Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.1 additional information
-
 IC50: 100.23 microg/ml for corosolic acid, 1.82 microg/ml for acarbose Sus scrofa additional information
3.2.1.20 additional information
-
 IC50: 3.53 microg/ml for corosolic acid, 88.72 microg/ml for ethyl acetate extract, 6.29 microg/ml for oleanolic acid, 18.63 microg/ml for arjunolic acid, 30.03 microg/ml for asiatic acid, 5.52 microg/ml for maslinic acid, 8.14 microg/ml for 23-hydroxyursolic acid Saccharomyces cerevisiae additional information