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Literature summary extracted from

  • Lee, S.S.; Lin, H.C.; Chen, C.K.
    Acylated flavonol monorhamnosides, alpha-glucosidase inhibitors, from Machilus philippinensis (2008), Phytochemistry, 69, 2347-2353.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.20 medicine inhibitors may serve as lead to develop drugs for treatment of type 2 diabetes Geobacillus stearothermophilus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.20 3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 acarbose
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(2'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(2'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(2''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(3'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside 3'',4''-di-Ep-coumaroic acid ester, acylated flavonol monorhamnoside, alpha-glucosidase inhibitor, from Machilus philippinensis Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside 3''-(E),4''-(Z)-di-p-coumaroic acid ester, acylated flavonol monorhamnoside, alpha-glucosidase inhibitor, from Machilus philippinensis Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol 3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 kaempferol-3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 luteolin
-
 Geobacillus stearothermophilus
3.2.1.20 quercetin 3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 quercetin 3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus
3.2.1.20 quercetin-3-O-rhamnopyranoside
-
 Geobacillus stearothermophilus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.20 Geobacillus stearothermophilus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.20 4-nitrophenyl alpha-D-glucopyranoside + H2O
-
 Geobacillus stearothermophilus 4-nitrophenol + alpha-D-glucopyranose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.20 alpha-glucosidase
-
 Geobacillus stearothermophilus
3.2.1.20 alpha-glucosidase type IV
-
 Geobacillus stearothermophilus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.20 additional information
-
 IC50 value for a mixture of kaempferol-3-O-alpha-L-(3'',4''-di-(E)-pcoumaroyl)-rhamnopyranosidekaempferol-3-O-alpha-L-rhamnopyranoside, kaempferol-3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside, quercetin-3-O-alpha-L-(3''-(Z),4''-(E)-di-p-coumaroyl)-rhamnopyranoside, quercetin-3-O-alpha-L-(3'',4''-di-(Z)-pcoumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(3''-(Z),4''-(E)-di-pcoumaroyl)-rhamnopyranoside,kaempferol-3-O-alpha-L-(3'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(2'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside, kaempferol-3-O-alpha-L-(2'',4''-di-(Z)-p-coumaroyl)-rhamnopyranoside, and kaempferol-3-O-alpha-L-(2''-(Z),4''-E-di-p-coumaroyl)-rhamnopyranoside: 0.00267 mM Geobacillus stearothermophilus additional information
3.2.1.20 0.000046
-
-
 Geobacillus stearothermophilus acarbose
3.2.1.20 0.001
-
-
 Geobacillus stearothermophilus kaempferol-3-O-alpha-L-(3''-(E),4''-(Z)-di-p-coumaroyl)-rhamnopyranoside
3.2.1.20 0.0061
-
-
 Geobacillus stearothermophilus kaempferol 3-O-alpha-L-(3'',4''-di-(E)-p-coumaroyl)-rhamnopyranoside
3.2.1.20 0.03305
-
-
 Geobacillus stearothermophilus quercetin-3-O-rhamnopyranoside
3.2.1.20 0.2281
-
-
 Geobacillus stearothermophilus kaempferol-3-O-rhamnopyranoside