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Literature summary extracted from

  • Munday, R.; Zhang, Y.; Munday, C.M.; Bapardekar, M.V.; Paonessa, J.D.
    Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates (2008), Pharm. Res., 25, 2164-2170.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 alpha-methylbenzyl isothiocyanate in vivo, the organ most susceptible to the inductive activity of the isothiocyanates is the urinary bladder, with alpha-methylbenzyl isothiocyanate and cyclohexylmethyl isothiocyanate being the most effective. Inductive activity in the bladder in vivo does not correlate with that in bladder cells in vitro Rattus norvegicus
1.6.5.2 cyclohexylmethyl isothiocyanate in vivo, the organ most susceptible to the inductive activity of the isothiocyanates is the urinary bladder, with alpha-methylbenzyl isothiocyanate and cyclohexylmethyl isothiocyanate being the most effective. Inductive activity in the bladder in vivo does not correlate with that in bladder cells in vitro Rattus norvegicus

Application

EC Number Application Comment Organism
1.6.5.2 drug development induction of phase 2 enzymes, e.g. NQO1 increases resistance to chemical carcinogenesis. Isothiocyanates can therefore be valuable chemopreventative agents, and the specificity of these substances toward the urinary bladder suggest that they may be particularly useful for protecting against bladder cancer Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
 female Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 duodenum
-
 Rattus norvegicus
-
1.6.5.2 forestomach
-
 Rattus norvegicus
-
1.6.5.2 ileum
-
 Rattus norvegicus
-
1.6.5.2 jejunum
-
 Rattus norvegicus
-
1.6.5.2 small intestine
-
 Rattus norvegicus
-
1.6.5.2 urinary bladder
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 menadione + NADH
-
 Rattus norvegicus reduced menadione + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD[P]H:quinone acceptor oxidoreductase 1
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Rattus norvegicus