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Literature summary extracted from

  • Ischenko, I.; Camaj, P.; Seeliger, H.; Kleespies, A.; Guba, M.; De Toni, E.N.; Schwarz, B.; Graeb, C.; Eichhorn, M.E.; Jauch, K.W.; Bruns, C.J.
    Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling (2008), Oncogene, 27, 7212-722.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 5-fluorouracil
-
Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.1 medicine a potential mechanism of action of Src kinase inhibitors on 5-fluorouracil chemosensitivity may be linked to the inhibition of 5-fluorouracil-induced EGFR-AKT activation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, combination of 5-fluorouracil-PP2 decreases the 5-fluorouracil-induced activation of EGFR-AKT pathway Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 AsPC-1 cell
-
Homo sapiens
-
2.7.10.1 L3.6pl cell
-
Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 Egfr
-
Homo sapiens
2.7.10.1 epidermal growth factor receptor
-
Homo sapiens