Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liang, L.; Deng, L.; Nguyen, S.C.; Zhao, X.; Maulion, C.D.; Shao, C.; Tischfield, J.A.
    Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks (2008), Nucleic Acids Res., 36, 3297-3310.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.1 nucleus
-
 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 46BR cell
-
 Homo sapiens
-
6.5.1.1 fibroblast
-
 Homo sapiens
-
6.5.1.1 HTD-114 cell
-
 Homo sapiens
-
6.5.1.1 WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase I DNA ligase I is required for 10bp-microhomology-mediated end joining Homo sapiens
6.5.1.1 DNA ligase III DNA ligase III is required in microhomology-mediated end joining Homo sapiens
6.5.1.1 DNA ligase IV DNA ligase IV is not required in microhomology-mediated end joining but facilitates Ku-dependent nonhomologous end-joining Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.1 ATP
-
 Homo sapiens