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Literature summary extracted from

  • Katyare, S.S.; Patel, S.P.; Modi, H.R.
    Diabetic modulation of the temperature kinetics properties of cytochrome oxidase activity in rat brain mitochondria (2008), Neurochem. Res., 33, 422-429.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.9 Insulin insulin treatment at early stage of diabetes (1-week diabetic animals) results in hyper-stimulation, but it is ineffective in restoring the activity in 1-month diabetic animals Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information enzyme activity decreases only at the late stage of diabetes which is not normalized by insulin treatment. Activity at room temperature (25°C) as well as at physiological temperature (37°C) is not affected by the diabetic state. At the late stage of diabetes the activity at 37°C decreases by 22% Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 adult male albino rats of Charles-Foster strain
-
7.1.1.9 Rattus norvegicus Charles-Foster
-
 adult male albino rats of Charles-Foster strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 2,3,5,6-tetramethyl-p-phenylenediamine + O2
-
 Rattus norvegicus ? + H2O
-
 ?
7.1.1.9 2,3,5,6-tetramethyl-p-phenylenediamine + O2
-
 Rattus norvegicus Charles-Foster ? + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 cytochrome c oxidase
-
 Rattus norvegicus