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Literature summary extracted from
- Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium (2009), Naunyn Schmiedebergs Arch. Pharmacol., 379, 379-384.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.53 | 3-isobutyl-1-methylxanthine | - |
Rattus norvegicus |  |
| 3.1.4.53 | additional information | not inhibited by cilostamide | Rattus norvegicus | |
| 3.1.4.53 | rolipram | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.53 | cardiac atrium | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.53 | 3',5'-cAMP + H2O | - |
Rattus norvegicus | 5'-AMP | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.53 | PDE4 | - |
Rattus norvegicus |
| 3.1.4.53 | phosphodiesterase 4 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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