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Literature summary extracted from

  • Neukam, K.; Pastor, N.; Cortes, F.
    Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells (2008), Mutat. Res., 654, 8-12.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 (+)-catechin
-
 Cricetulus griseus
5.6.2.2 (-)-epicatechin
-
 Cricetulus griseus
5.6.2.2 (-)-epigallocatechin
-
 Cricetulus griseus
5.6.2.2 (-)-epigallocatechin-3-gallate
-
 Cricetulus griseus

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Cricetulus griseus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.2.2 CHO-AA8 cell
-
 Cricetulus griseus
-
5.6.2.2 ovary
-
 Cricetulus griseus
-

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 topo II
-
 Cricetulus griseus
5.6.2.2 Topoisomerase II
-
 Cricetulus griseus

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Cricetulus griseus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.6.2.2 0.0372
-
-
 Cricetulus griseus (-)-epicatechin
5.6.2.2 0.046
-
-
 Cricetulus griseus (+)-catechin
5.6.2.2 3.61
-
-
 Cricetulus griseus (-)-epigallocatechin
5.6.2.2 3.78
-
-
 Cricetulus griseus (-)-epigallocatechin-3-gallate