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Literature summary extracted from

  • Uchaipichat, V.; Galetin, A.; Houston, J.B.; Mackenzie, P.I.; Williams, J.A.; Miners, J.O.
    Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites (2008), Mol. Pharmacol., 74, 1152-1162.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 stable expression of isozyme UGT2B7 Tyr268 variant in HEK-293 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UGT2B7 provides evidence for multiple substrate binding and effector sites, multisite kinetic equilibria models and two-site inhibition model for a substrate exhibiting Michaelis-Menten kinetics, three-site model for heteroactivation, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P16662
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UGT2B7 provides evidence for multiple substrate binding and effector sites, overview Homo sapiens ?
-
 ?
2.4.1.17 UDP-D-glucuronate + 1-naphthol
-
 Homo sapiens UDP + 1-naphthyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + 4-methylumbelliferonyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + zidovudine
-
 Homo sapiens UDP + zidovudine beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 2B7
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens