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Literature summary extracted from

  • Fไlker, S.; Nelson, A.L.; Morfeldt, E.; Jonas, K.; Hultenby, K.; Ries, J.; Melefors, O.; Normark, S.; Henriques-Normark, B.
    Sortase-mediated assembly and surface topology of adhesive pneumococcal pili (2008), Mol. Microbiol., 70, 595-607.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.B63 additional information Streptococcus pneumoniae of the three genes for structural subunits, rrgB encodes the major pilin, while rrgA and rrgC encode ancillary pilin subunits decorating the pilus shaft and tip. Deletion of all three pilus associated sortase genes, srtB, srtC and srtD, completely prevents pilus biogenesis. Both SrtB and SrtC act as pilus subunit polymerases, with SrtB processing all three pilus subunit proteins, while SrtC processes only RrgB and RrgA ?
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3.4.22.B64 additional information Streptococcus pneumoniae of the three genes for structural subunits, rrgB encodes the major pilin, while rrgA and rrgC encode ancillary pilin subunits decorating the pilus shaft and tip. Deletion of all three pilus associated sortase genes, srtB, srtC and srtD, completely prevents pilus biogenesis. SrtD does not act as a pilus subunit polymerase, but instead is required for wild-type focal presentation of the pilus at the cell surface ?
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Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B63 Streptococcus pneumoniae
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3.4.22.B64 Streptococcus pneumoniae
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B63 additional information of the three genes for structural subunits, rrgB encodes the major pilin, while rrgA and rrgC encode ancillary pilin subunits decorating the pilus shaft and tip. Deletion of all three pilus associated sortase genes, srtB, srtC and srtD, completely prevents pilus biogenesis. Both SrtB and SrtC act as pilus subunit polymerases, with SrtB processing all three pilus subunit proteins, while SrtC processes only RrgB and RrgA Streptococcus pneumoniae ?
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 ?
3.4.22.B64 additional information of the three genes for structural subunits, rrgB encodes the major pilin, while rrgA and rrgC encode ancillary pilin subunits decorating the pilus shaft and tip. Deletion of all three pilus associated sortase genes, srtB, srtC and srtD, completely prevents pilus biogenesis. SrtD does not act as a pilus subunit polymerase, but instead is required for wild-type focal presentation of the pilus at the cell surface Streptococcus pneumoniae ?
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