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Literature summary extracted from

  • Du, M.; Perry, R.L.; Nowacki, N.B.; Gordon, J.W.; Salma, J.; Zhao, J.; Aziz, A.; Chan, J.; Siu, K.W.; McDermott, J.C.
    Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D (2008), Mol. Cell. Biol., 28, 2952-2970.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.11.11 medicine activation of protein kinase A by elevation of the intracellular cAMP level inhibits skeletal myogenesis Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 expressed in C2C12 cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 myoblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + myocyte enhancer factor 2D myocyte enhancer factor 2D serine 121 and serine 190 are targeted by PKA Mus musculus ADP + phosphorylated myocyte enhancer factor 2D
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.11 heterotetramer the inactive enzyme is composed of two catalytic and two regulatory subunits Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 pFC-PKA catalytic subunit of PKA Mus musculus
2.7.11.11 PKA
-
 Mus musculus
2.7.11.11 protein kinase A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Mus musculus
2.7.11.11 cAMP dependent Mus musculus