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Literature summary extracted from

  • Bavaresco, L.; Bernardi, A.; Braganhol, E.; Cappellari, A.R.; Rockenbach, L.; Farias, P.F.; Wink, M.R.; Delgado-Canedo, A.; Battastini, A.M.
    The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation (2008), Mol. Cell. Biochem., 319, 61-68.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 adenosine 5'-(alpha,beta-methylene)diphosphate treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole Homo sapiens
3.1.3.5 adenosine 5'-(alpha,beta-methylene)diphosphate treatment with 0.001 mM adenosine 5'-(alpha,beta-methylene)diphosphate, a competitive ecto-5'-NT/CD73 inhibitor, causes a significant reduction of 30% in glioma cell proliferation, the inhibitory effect on cell proliferation caused by adenosine 5'-(alpha,beta-methylene)diphosphate is reverted by cotreatment with nitrobenzylthioinosine and dipyridamole Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.5 plasma membrane the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage Homo sapiens 5886
-
3.1.3.5 plasma membrane the enzyme is anchored on the outer surface of the plasma membrane via a glycosyl phosphatidylinositol linkage Rattus norvegicus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Homo sapiens
-
-
-
3.1.3.5 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.3.5 glycoprotein
-
 Homo sapiens
3.1.3.5 glycoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 C6 glioma cell
-
 Rattus norvegicus
-
3.1.3.5 glioma cell
-
 Homo sapiens
-
3.1.3.5 glioma cell
-
 Rattus norvegicus
-
3.1.3.5 U-138MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
3.1.3.5 5'-AMP + H2O
-
 Rattus norvegicus adenosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.5 CD73
-
 Homo sapiens
3.1.3.5 CD73
-
 Rattus norvegicus
3.1.3.5 ecto-5'-NT
-
 Homo sapiens
3.1.3.5 ecto-5'-NT
-
 Rattus norvegicus
3.1.3.5 ecto-5'-NT/CD73
-
 Homo sapiens
3.1.3.5 ecto-5'-NT/CD73
-
 Rattus norvegicus
3.1.3.5 ecto-5'-nucleotidase
-
 Homo sapiens
3.1.3.5 ecto-5'-nucleotidase
-
 Rattus norvegicus