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Literature summary extracted from

  • Wu, Y.; Preston, G.; Bianco, A.E.
    Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi (2008), Mol. Biochem. Parasitol., 161, 55-62.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.14 allosamidin complete inhibition at 5 nM Brugia malayi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.14 extracellular chitinase is stored and secreted from the inner body of microfilariae via either the pharyngeal thread, or during transmission of the microfilariae to the vector, contained in vesicle-like structures Brugia malayi
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3.2.1.14 microfilarial stage chitinase is stored and secreted from the inner body of microfilariae Brugia malayi
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Organism

EC Number Organism UniProt Comment Textmining
3.2.1.14 Brugia malayi P29030 parasitic nematode in Onchocerca volvulus larvae
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.14 additional information nematodes are cultured in Meriones unguiculatus, Mongolian jirds, and Aedes aegypti mosquitos as hosts of different larval stages, overview Brugia malayi
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.14 4-methylumbelliferyl GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
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 Brugia malayi 4-methylumbelliferone + GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAc
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 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.14 37
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 assay at Brugia malayi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.14 7.4
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 assay at Brugia malayi