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Literature summary extracted from

  • Murthy, K.S.
    Inhibitory phosphorylation of soluble guanylyl cyclase by muscarinic m2 receptors via Gbetagamma-dependent activation of c-Src kinase (2008), J. Pharmacol. Exp. Ther., 325, 183-189.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO
-
 Oryctolagus cuniculus
4.6.1.2 S-nitrosoglutathione stimulates the enzyme activity via NO production, stimulation is inhibited by acetylcholine Oryctolagus cuniculus
4.6.1.2 YC-1 an NO-independent activator of sGC Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 additional information c-Src-dependent phosphorylation of sGC in induced by acetylcholine and inhibits NO-sensitive sGC activity and cGMP production Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Oryctolagus cuniculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.2 Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Oryctolagus cuniculus cGMP levels in response to relaxant agonists are regulated in gastrointestinal smooth muscle by activation of phosphodiesterase 5 and inhibition of soluble guanylyl cyclase by c-Src-dependent phosphorylation in a feedback mechanism via the cGMP-dependent protein kinase, mechanism for attenuation of the NO/sGC/cGMP signal by Gi-coupled contractile agonists, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Oryctolagus cuniculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.6.1.2 phosphoprotein c-Src-dependent phosphorylation of sGC, inhibits NO-sensitive sGC activity. Phosphorylation sGC is blocked by methoctramine, pertussis toxin, LY294002, or PP2, but not by m3 receptor antagonist 4-DAMP, regulation of sGC phosphorylation Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 smooth muscle gastrointestinal smooth muscle Oryctolagus cuniculus
-
4.6.1.2 stomach gastrointestinal smooth muscle Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Oryctolagus cuniculus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP cGMP levels in response to relaxant agonists are regulated in gastrointestinal smooth muscle by activation of phosphodiesterase 5 and inhibition of soluble guanylyl cyclase by c-Src-dependent phosphorylation in a feedback mechanism via the cGMP-dependent protein kinase, mechanism for attenuation of the NO/sGC/cGMP signal by Gi-coupled contractile agonists, overview Oryctolagus cuniculus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Oryctolagus cuniculus
4.6.1.2 soluble guanylyl cyclase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.2 37
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.2 7.4
-
 assay at Oryctolagus cuniculus