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Literature summary extracted from

  • Hu, M.; Waring, J.F.; Gopalakrishnan, M.; Li, J.
    Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells (2008), J. Neurochem., 106, 1371-1377.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.26 beta-amyloid peptide 1-42 0.01 mM, induces phosphorylation at Tyr216 activating GSK-3beta Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.26 A-582941 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
2.7.11.26 alpha-bungarotoxin attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
2.7.11.26 CHIR98023 attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
2.7.11.26 methyllycaconitine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus
2.7.11.26 Nicotine attenuates beta-amyloid peptide 1-42-induced activation of GSK-3beta Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase-3beta
-
 Rattus norvegicus
2.7.11.26 GSK-3beta
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
 Rattus norvegicus