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Literature summary extracted from
- Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B (2008), J. Nat. Prod., 71, 1775-1778.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.48 | 19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid | - |
Homo sapiens |  |
| 3.1.3.48 | 24-hydroxyursolic acid | - |
Homo sapiens | |
| 3.1.3.48 | additional information | 3alpha,24,29-trihydroxyolean-12-en-28-oic acid, 3alpha,19alpha-dihydroxyurs-12,20(30)-dien-24,28-dioic acid, and 3alpha,19alpha-dihydroxyurs-12-en-24,28-dioic acid show very weak inhibitory effect towards PTP1B | Homo sapiens | |
| 3.1.3.48 | oleanolic acid | - |
Homo sapiens | |
| 3.1.3.48 | oleanonic acid | - |
Homo sapiens | |
| 3.1.3.48 | pomolic acid | - |
Homo sapiens | |
| 3.1.3.48 | RK-682 | - |
Homo sapiens | |
| 3.1.3.48 | rotungenic acid | - |
Homo sapiens | |
| 3.1.3.48 | spathodic acid | - |
Homo sapiens | |
| 3.1.3.48 | ursolic acid | - |
Homo sapiens | |
| 3.1.3.48 | uvaol | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.48 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.48 | phosphorylated phospholipase Cgamma + H2O | dephosphorylation occurs at Tyr-783 | Homo sapiens | phospholipase Cgamma + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.48 | protein tyrosine phosphatase 1B | - |
Homo sapiens |
| 3.1.3.48 | PTP1B | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.48 | 0.0031 | - |
- |
Homo sapiens | ursolic acid | |
| 3.1.3.48 | 0.0035 | - |
- |
Homo sapiens | oleanonic acid | |
| 3.1.3.48 | 0.0039 | - |
- |
Homo sapiens | pomolic acid | |
| 3.1.3.48 | 0.0041 | - |
- |
Homo sapiens | RK-682 | |
| 3.1.3.48 | 0.0076 | - |
- |
Homo sapiens | oleanolic acid | |
| 3.1.3.48 | 0.0081 | - |
- |
Homo sapiens | 19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid | |
| 3.1.3.48 | 0.0109 | - |
- |
Homo sapiens | rotungenic acid | |
| 3.1.3.48 | 0.0128 | - |
- |
Homo sapiens | 24-hydroxyursolic acid | |
| 3.1.3.48 | 0.0156 | - |
- |
Homo sapiens | uvaol | |
| 3.1.3.48 | 0.0188 | - |
- |
Homo sapiens | spathodic acid | |
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