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Literature summary extracted from

  • Han, S.J.; Park, S.W.; Park, B.W.; Sim, S.J.
    Selective production of epothilone B by heterologous expression of propionyl-CoA synthetase in Sorangium cellulosum (2008), J. Microbiol. Biotechnol., 18, 135-137.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.17 gene prpE, functional expression in Sorangium cellulosum So ce90 leading to a significant increase in the resolution of epothilones B/A, with an epothilone B to A ratio of 127 to 1, which is 100times higher than that of the wild-type cells Ralstonia solanacearum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.17 Mg2+
-
 Ralstonia solanacearum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA Ralstonia solanacearum propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent AMP + diphosphate + propanoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.17 Ralstonia solanacearum
-
 gene prpE
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA
-
 Ralstonia solanacearum AMP + diphosphate + propanoyl-CoA
-
 ?
6.2.1.17 ATP + propanoate + CoA propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent Ralstonia solanacearum AMP + diphosphate + propanoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.17 Propionyl-CoA synthetase
-
 Ralstonia solanacearum

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.17 ATP
-
 Ralstonia solanacearum