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Literature summary extracted from
- Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase (2008), J. Med. Chem., 51, 432-438.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.23 | into the vector pET15b for expression in Escherichia coli BL21 cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.23 | AMP | - |
Homo sapiens |  |
| 4.1.1.23 | AMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | CMP | - |
Homo sapiens | |
| 4.1.1.23 | CMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | dAMP | - |
Homo sapiens | |
| 4.1.1.23 | dAMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | GMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | GMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | IMP | - |
Homo sapiens | |
| 4.1.1.23 | IMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | IMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | TMP | - |
Homo sapiens | |
| 4.1.1.23 | TMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | TMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | UMP | - |
Homo sapiens | |
| 4.1.1.23 | UMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | UMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | XMP | - |
Homo sapiens | |
| 4.1.1.23 | XMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | XMP | - |
Plasmodium falciparum | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.0013 | - |
orotidine 5'-phosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 0.0017 | - |
orotidine 5'-phosphate | - |
Homo sapiens | |
| 4.1.1.23 | 0.0048 | - |
orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 27340 | - |
- |
Methanothermobacter thermautotrophicus |
| 4.1.1.23 | 31710 | - |
- |
Homo sapiens |
| 4.1.1.23 | 39850 | - |
- |
Plasmodium falciparum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | Orotidine 5'-phosphate | Homo sapiens | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Plasmodium falciparum | - |
UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | Methanothermobacter thermautotrophicus | - |
UMP + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.23 | Homo sapiens | - |
- |
- |
| 4.1.1.23 | Methanothermobacter thermautotrophicus | O26232 | - |
- |
| 4.1.1.23 | Plasmodium falciparum | Q8IJH3 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.23 | using a Ni and a gel filtration column, the His6-tag is removed by thrombin digestion | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? | |
| 4.1.1.23 | Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.23 | ODCase | - |
Homo sapiens |
| 4.1.1.23 | ODCase | - |
Plasmodium falciparum |
| 4.1.1.23 | ODCase | - |
Methanothermobacter thermautotrophicus |
| 4.1.1.23 | Orotidine monophosphate decarboxylase | - |
Homo sapiens |
| 4.1.1.23 | Orotidine monophosphate decarboxylase | - |
Plasmodium falciparum |
| 4.1.1.23 | Orotidine monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 37 | - |
activity assay | Homo sapiens |
| 4.1.1.23 | 37 | - |
activity assay | Plasmodium falciparum |
| 4.1.1.23 | 55 | - |
activity assay | Methanothermobacter thermautotrophicus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 6.7 | - |
orotidine 5'-phosphate | - |
Plasmodium falciparum | |
| 4.1.1.23 | 8.1 | - |
orotidine 5'-phosphate | - |
Homo sapiens | |
| 4.1.1.23 | 20.7 | - |
orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.23 | 7.4 | - |
activity assay | Plasmodium falciparum |
| 4.1.1.23 | 7.5 | - |
activity assay | Homo sapiens |
| 4.1.1.23 | 7.5 | - |
activity assay | Methanothermobacter thermautotrophicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.23 | 0.0007 | - |
XMP | - |
Homo sapiens | |
| 4.1.1.23 | 0.043 | - |
XMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | 0.13 | - |
XMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 0.21 | - |
UMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | 0.22 | - |
UMP | - |
Homo sapiens | |
| 4.1.1.23 | 0.33 | - |
UMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 1.2 | - |
CMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 1.4 | - |
CMP | - |
Homo sapiens | |
| 4.1.1.23 | 2.1 | - |
GMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | 3.3 | - |
TMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 3.5 | - |
AMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 4 | - |
IMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | 4.2 | - |
GMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 4.3 | - |
AMP | - |
Homo sapiens | |
| 4.1.1.23 | 5.7 | - |
IMP | - |
Methanothermobacter thermautotrophicus | |
| 4.1.1.23 | 7.2 | - |
IMP | - |
Homo sapiens | |
| 4.1.1.23 | 7.4 | - |
dAMP | - |
Homo sapiens | |
| 4.1.1.23 | 8.7 | - |
TMP | - |
Homo sapiens | |
| 4.1.1.23 | 10 | - |
TMP | - |
Plasmodium falciparum | |
| 4.1.1.23 | 10 | - |
dAMP | above 10 mM | Methanothermobacter thermautotrophicus | |
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