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Literature summary extracted from

  • Jongstra-Bilen, J.; Puig Cano, A.; Hasija, M.; Xiao, H.; Smith, C.I.; Cybulsky, M.I.
    Dual functions of Brutons tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis (2008), J. Immunol., 181, 288-298.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information Btk activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate Mus musculus
2.7.10.2 additional information Tec activation is induced by FcgammaR signaling, activation requires binding to phosphatidylinositol 3,4,5-trisphosphate Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 LFM-A13
-
 Mus musculus
2.7.10.2 siRNA
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Mus musculus
-
-
-
2.7.10.2 Mus musculus P24604
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein phosphorylation by other kinases and autophosphorylation Mus musculus
2.7.10.2 phosphoprotein phosphorylation by other kinases and autophosphorylation at Tyr223 of Btk Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 peritoneal macrophage
-
 Mus musculus
-
2.7.10.2 RAW-264.7 cell
-
 Mus musculus
-
2.7.10.2 splenocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Brutons tyrosine kinase
-
 Mus musculus
2.7.10.2 Btk
-
 Mus musculus
2.7.10.2 Tec kinase
-
 Mus musculus