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Literature summary extracted from

  • Zheng, M.; Gu, X.; Zheng, D.; Yang, Z.; Li, F.; Zhao, J.; Xie, Y.; Ji, C.; Mao, Y.
    UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins (2008), J. Cell. Biochem., 104, 2324-2334.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.45 expressed in Escherichia coli Rosetta cells and in AD-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.45 cytoplasm predominant localization Homo sapiens 5737
-
6.2.1.45 cytoplasm UBE1DC1 is especially distributed in the cytoplasm of AD-293 cells Homo sapiens 5737
-
6.2.1.45 nucleus UBE1DC1 is mainly distributed in the nucleus of AD-293 cells when cotransfected with its substrate SUMO2 Homo sapiens 5634
-
6.2.1.45 nucleus predominant localization upon cotransfection with small ubiquitin-like modifier SUMO2 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.45 Homo sapiens Q9GZZ9
-
-
6.2.1.45 Homo sapiens Q9GZZ9 isoform UBA5
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.45 Ni-NTA column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.45 brain fetal brain Homo sapiens
-
6.2.1.45 kidney embryonic kidney Homo sapiens
-
6.2.1.45 liver
-
 Homo sapiens
-
6.2.1.45 pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.45 ATP + SUMO2 + [ubiquitin-activating protein UBA5]-L-cysteine SUMO2, small ubiquitin-like modifier2, an ubiquitin-like protein Homo sapiens AMP + diphosphate + [ubiquitin-activating protein UBA5]-S-SUMO2-L-cysteine enzyme greatly activates SUMO2 in the nucleus or transfers activated SUMO2 to the nucleus after it conjugated SUMO2 in the cytoplasm ?
6.2.1.45 ATP + ubiquitin + SUMO2 UBE1DC1 greatly activates SUMO2 in the nucleus or transfers activated-SUMO2 to nucleus after conjugation of SUMO2 in the cytoplasm Homo sapiens ?
-
 ?
6.2.1.45 ATP + ubiquitin + ubiquitin-fold modifier 1
-
 Homo sapiens ?
-
 ?
6.2.1.45 ATP + ubiquitin + Ufm1
-
 Homo sapiens ?
-
 ?
6.2.1.45 ATP + Ufm1 + [ubiquitin-activating protein UBA5]-L-cysteine Ufm1, ubiquitin-fold modifier 1, an ubiquitin-like protein Homo sapiens AMP + diphosphate + [ubiquitin-activating protein UBA5]-S-Ufm1-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.45 UBA5
-
 Homo sapiens
6.2.1.45 UBE1DC1
-
 Homo sapiens
6.2.1.45 UBE1DC1A isoform Homo sapiens
6.2.1.45 UBE1DC1B isoform Homo sapiens
6.2.1.45 ubiquitin-activating enzyme E1 domain-containing protein 1
-
 Homo sapiens
6.2.1.45 ubiquitin-activating enzyme E1-domain containing 1
-
 Homo sapiens