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Literature summary extracted from

  • Maron, B.A.; Zhang, Y.Y.; Handy, D.E.; Beuve, A.; Tang, S.S.; Loscalzo, J.; Leopold, J.A.
    Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells (2009), J. Biol. Chem., 284, 7665-7672.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO activates the soluble guanylyl cyclase Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression of wild-type and C122A mutant enzymes in COS-7 cells Bos taurus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 C122A site-directed mutagenesis of the aldosterone modification site, the mutant is insensitive to inhibition by aldosterone or H2O2 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 aldosterone diminishes GC activity by activating NADPH oxidase in bovine aortic VSMC to increase ROS levels and induce oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue Bos taurus
4.6.1.2 H2O2 diminishes GC activity by activating NADPH oxidase in bovine aortic VSMC to increase ROS levels and induce oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 cytosol
-
 Bos taurus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Bos taurus sGC produces cGMP, a second messenger required for normal vascular smooth muscle cell, VSMC, relaxation. Activating NADPH oxidase in bovine aortic VSMC increases ROS levels and induces oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue of the guanylate cyclase leading to its inhibition 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 aorta
-
 Bos taurus
-
4.6.1.2 blood vessel
-
 Bos taurus
-
4.6.1.2 smooth muscle cell vascular Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP sGC produces cGMP, a second messenger required for normal vascular smooth muscle cell, VSMC, relaxation. Activating NADPH oxidase in bovine aortic VSMC increases ROS levels and induces oxidative posttranslational modification of Cys122, a beta1-subunit cysteinyl residue of the guanylate cyclase leading to its inhibition Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.6.1.2 dimer the soluble guanylyl cyclase forms a heterodimer Bos taurus

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 soluble guanylyl cyclase
-
 Bos taurus