Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Basu, N.K.; Kole, L.; Basu, M.; Chakraborty, K.; Mitra, P.S.; Owens, I.S.
    The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C (2008), J. Biol. Chem., 283, 23048-23061.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 additional information the regulatory domain of PKC leading to activation, and H2O2 activates PKC via increased phosphorylation of tyrosine in its catalytic domain Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of UGT isozymes in COS-1 cells with co-localization of isozyme UGT1A7His and PKCepsilon and of isoyzme UGT1A10His andPKCalpha orPKCgamma Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 calphostin-C
-
 Homo sapiens
2.4.1.17 curcumin reversable by low glucuronidation activity with curcumin as substrate, overview Homo sapiens
2.4.1.17 additional information inhibition of UGT activity by PKCepsilon-specific antagonist peptide or by PKCapsilon-targeted destruction with PKCepsilon-specific small interference RNA and activation of curcumin-down-regulated UGTs with typical PKC agonists verify a central PKC role in glucuronidation, overview. UGT down-regulation by the tyrosine kinase-specific inhibitor, herbimycin-A, suggests cellular oxidant-/H2O2-activated PKC via tyrosine phosphorylation also plays a role in sustaining UGT activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum co-localization of UGTs with protein kinases C, overview Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.17 phosphoprotein UGT isozymes are phosphorylated by active protein kinases Cepsilon, Calpha, and Cgamma, analysis of UGT phosphorylation, overview Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 colon
-
 Homo sapiens
-
2.4.1.17 gastrointestinal tract
-
 Homo sapiens
-
2.4.1.17 kidney
-
 Homo sapiens
-
2.4.1.17 liver
-
 Homo sapiens
-
2.4.1.17 LS-180 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information specific phospho-groups in UGT1A7 determine substrate selections, suggests regulated phosphorylation allows adaptations regarding differential phosphate utilization by UGTs to function efficiently Homo sapiens ?
-
 ?
2.4.1.17 UDP-D-glucuronate + 4-nitrophenol
-
 Homo sapiens UDP + 4-nitrophenyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + anthraflavic acid
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + apigenin
-
 Homo sapiens UDP + apigenin 7-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + bilirubin
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 UDP-D-glucuronate + capsaicin
-
 Homo sapiens UDP + capsaicin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + curcumin low activity, can reverse the inhibitory effect of curcumin on UGTs Homo sapiens UDP + curcumin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + estriol
-
 Homo sapiens UDP + estriol 3-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + eugenol
-
 Homo sapiens UDP + eugenol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + phenolphthalein
-
 Homo sapiens UDP + phenolphthalein beta-D-monoglucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + phloretin
-
 Homo sapiens UDP + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 ? x * 52000-55000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.17 6.4 7.6
-
 Homo sapiens