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Literature summary extracted from

  • Lee, H.; Cho, J.S.; Lambacher, N.; Lee, J.; Lee, S.J.; Lee, T.H.; Gartner, A.; Koo, H.S.
    The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior (2008), J. Biol. Chem., 283, 14988-14993.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 AMP
-
 Caenorhabditis elegans
2.7.11.31 additional information AAK-2 is phosphorylated at Thr243 and activated in response to paraquat treatment, the phosphorylation depends on PAR-4, the Caenorhabditis elegans LKB1 homologue Caenorhabditis elegans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 expression of the GFP-tagged AAK-2 in transgenic worms Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.31 additional information aak-2 mutation and par-4 knockdown increase the sensitivity of worms to paraquat, and the double deficiency does not further increase sensitivity Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.31 additional information Caenorhabditis elegans AMPK can influence the behavior of Caenorhabditis elegans worms in addition to its well known function in metabolic control, aak-1 and aak-2 affect paraquat sensitivity of adult worms, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Caenorhabditis elegans
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.31 phosphoprotein AAK-2 is phosphorylated at Thr243 in response to paraquat treatment, the phosphorylation depends on PAR-4, the Caenorhabditis elegans LKB1 homologue Caenorhabditis elegans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 body wall muscle
-
 Caenorhabditis elegans
-
2.7.11.31 excretory gland
-
 Caenorhabditis elegans
-
2.7.11.31 gonad somatic gonad Caenorhabditis elegans
-
2.7.11.31 neuron
-
 Caenorhabditis elegans
-
2.7.11.31 pharynx
-
 Caenorhabditis elegans
-
2.7.11.31 ventral nerve cord
-
 Caenorhabditis elegans
-
2.7.11.31 vulva
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 additional information AMPK can influence the behavior of Caenorhabditis elegans worms in addition to its well known function in metabolic control, aak-1 and aak-2 affect paraquat sensitivity of adult worms, overview Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AAK-2
-
 Caenorhabditis elegans
2.7.11.31 AMP-activated protein kinase
-
 Caenorhabditis elegans
2.7.11.31 AMPK
-
 Caenorhabditis elegans