Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kline, K.A.; Kau, A.L.; Chen, S.L.; Lim, A.; Pinkner, J.S.; Rosch, J.; Nallapareddy, S.R.; Murray, B.E.; Henriques-Normark, B.; Beatty, W.; Caparon, M.G.; Hultgren, S.J.
    Mechanism for sortase localization and role in efficient pilus assembly in Enterococcus faecalis (2009), J. Bacteriol., 191, 3237-3247.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.B63 additional information mutation or deletion of the positively charged domain flanking a transmembrane helix in SrtC abolishes both its retention at single foci and its function in efficient pilus assembly. This positively charged domain can act as a localization retention signal for the focal compartmentalization of membrane proteins Enterococcus faecalis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.B63 membrane focal localization of SrtC is necessary for efficient pilus formation Enterococcus faecalis 16020
-
3.4.22.70 membrane sortase A (SrtA) colocalizes with SecA at single foci in the enterococcus. Proteins that localize to single foci in Enterococcus faecalis share a positively charged domain flanking a transmembrane helix. Positively charged domain can act as a localization retention signal for the focal compartmentalization of the membrane protein Enterococcus faecalis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.B63 additional information Enterococcus faecalis the enzyme is required for efficient pilusassembly ?
-
 ?
3.4.22.70 additional information Enterococcus faecalis sortase localization is facilitated by a positive charge that is necessary for efficient pilus biogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B63 Enterococcus faecalis
-
-
-
3.4.22.70 Enterococcus faecalis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B63 additional information the enzyme is required for efficient pilusassembly Enterococcus faecalis ?
-
 ?
3.4.22.70 additional information sortase localization is facilitated by a positive charge that is necessary for efficient pilus biogenesis Enterococcus faecalis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B63 SrtC
-
 Enterococcus faecalis
3.4.22.70 SrtA
-
 Enterococcus faecalis