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Literature summary extracted from

  • Kazakov, T.; Vondenhoff, G.H.; Datsenko, K.A.; Novikova, M.; Metlitskaya, A.; Wanner, B.L.; Severinov, K.
    Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C (2008), J. Bacteriol., 190, 2607-2610.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.12 heptapeptide-nucleotide microcin C i.e. McC, upon its entry into a susceptible cell, McC is processed to release a nonhydrolyzable aspartyl-adenylate that inhibits aspartyl-tRNA synthetase, leading to the cessation of translation and cell growth. The rate-limiting step of McC processing in vitro is deformylation of the first methionine residue of McC Escherichia coli
6.1.1.23 heptapeptide-nucleotide microcin C McC, an antimicrobial nucleotide peptide that targets and strongly inhibits aspartyl-tRNA synthetase. The inhibitor cannot be processed by the nonspecific oligopeptidases PepA, PepB, or PepN, the rate-limiting step of McC processing in vitro is deformylation of the first methionine residue of McC, structure, massspectrometric analysis of McC produced by wild-type Escherichia coli cells, overview Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.12 Mg2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.12 ATP + L-aspartate + tRNAAsp Escherichia coli
-
 AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.4 Escherichia coli
-
-
-
6.1.1.12 Escherichia coli
-
-
-
6.1.1.23 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.4 microcin C + H2O microcin C is processed to a nonhydrolyzable analog of aspartyl-adenylate Escherichia coli ?
-
 ?
6.1.1.12 ATP + L-aspartate + tRNAAsp
-
 Escherichia coli AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.4 PepB
-
 Escherichia coli
3.4.11.4 peptidase B
-
 Escherichia coli
6.1.1.12 Asp-RS
-
 Escherichia coli
6.1.1.12 Aspartyl-tRNA synthetase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.12 ATP
-
 Escherichia coli