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Literature summary extracted from

  • Ruiz-Maso, J.A.; Anand, S.P.; Espinosa, M.; Khan, S.A.; del Solar, G.
    Genetic and biochemical characterization of the Streptococcus pneumoniae PcrA helicase and its role in plasmid rolling circle replication (2006), J. Bacteriol., 188, 7416-7425.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.2.3 ssDNA stimulates ATPase activity Streptococcus pneumoniae
5.6.2.4 ssDNA stimulates ATPase activity Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.2.3 ATP + H2O Streptococcus pneumoniae PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids ADP + phosphate
-
 ?
5.6.2.4 ATP + H2O Streptococcus pneumoniae PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.3 Streptococcus pneumoniae Q8DPU8
-
-
5.6.2.4 Streptococcus pneumoniae Q8DPU8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.3 ATP + H2O PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids Streptococcus pneumoniae ADP + phosphate
-
 ?
5.6.2.3 ATP + H2O hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' DNA helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand Streptococcus pneumoniae ADP + phosphate
-
 ?
5.6.2.3 dATP + H2O hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand Streptococcus pneumoniae dADP + phosphate
-
 ?
5.6.2.3 additional information the enzyme is inefficient in in vitro replication of pT181, and perhaps as a consequence, this plasmid can not be established in Streptococcus pneumoniae Streptococcus pneumoniae ?
-
 ?
5.6.2.4 ATP + H2O PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids Streptococcus pneumoniae ADP + phosphate
-
 ?
5.6.2.4 ATP + H2O hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' DNA helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand Streptococcus pneumoniae ADP + phosphate
-
 ?
5.6.2.4 dATP + H2O hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand Streptococcus pneumoniae dADP + phosphate
-
 ?
5.6.2.4 additional information the enzyme is inefficient in in vitro replication of pT181, and perhaps as a consequence, this plasmid can not be established in Streptococcus pneumoniae Streptococcus pneumoniae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.3 PcrA helicase
-
 Streptococcus pneumoniae
5.6.2.3 PcrASpn
-
 Streptococcus pneumoniae
5.6.2.4 PcrA helicase
-
 Streptococcus pneumoniae
5.6.2.4 PcrASpn
-
 Streptococcus pneumoniae