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Literature summary extracted from

  • Mann, L.; Heldman, E.; Shaltiel, G.; Belmaker, R.H.; Agam, G.
    Lithium preferentially inhibits adenylyl cyclase V and VII isoforms (2008), Int. J. Neuropsychopharmacol., 11, 533-539.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 A23187 activates isozymes AC-I and AC-III Mus musculus
4.6.1.1 forskolin activates isozymes AC-I to AC-VIII, but not AC-IX, which contains no forskolin binding site Mus musculus
4.6.1.1 additional information superactivation method for the isozymes, overview Mus musculus
4.6.1.1 SKF-82958 a D1 dopaminergic receptor agonist Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 overexpression of nine membrane-bound isozymes in COS7 cells in absence of the D1 receptor Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 Li+ lithium preferentially inhibits adenylyl cyclase V and VII isoforms, moderately also isozyme AC-II, but does not inhibit Ca2+-activated isozymes AC-I and AC-VIII, it interferes with the transduction pathways mediated via isozymes AC-V and AC-IIV. The inhibitor effect is abolished for the superactivated isozyme, overview Mus musculus
4.6.1.1 quinpirole inhibits the enzyme via Gi protein Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane nine membrane-bound isozymes Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Ca2+ stimulates the Ca2+-activated isozymes Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Mus musculus
-
 isozymes AC-I-AC-IX
-

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.1 37
-
 assay at Mus musculus