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Literature summary extracted from

  • Jin, Z.X.; Huang, C.R.; Dong, L.; Goda, S.; Kawanami, T.; Sawaki, T.; Sakai, T.; Tong, X.P.; Masaki, Y.; Fukushima, T.; Tanaka, M.; Mimori, T.; Tojo, H.; Bloom, E.T.; Okazaki, T.; Umehara, H.
    Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells (2008), Int. Immunol., 20, 1427-1437.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 gene SMS1, expression in Jurkat cells, expression levels, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.27 additional information knockout of SMS1 in T-cells by transfection of SMS1-short-interfering RNA into Jurkat T cells, impaired TCR signaling through dysfunction of lipid rafts in SMS1-knockdown T cells, overview. CD3-induced tyrosine phosphorylation and association of linker for activation of T cell with ZAP-70 and Grb2 and phosphorylation of protein kinase C are also severely impaired in Jurkat-SMS1/kd cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.27 lysenin is a sphingomyelin-directed cytolysin purified from the earthworm, which specifically binds to membrane sphingomyelin and induces pore formation in the plasma membrane and subsequent cell death Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 additional information Homo sapiens membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens
-
 gene SMS1 encoding isozyme SMS1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 additional information membrane sphingomyelin is a key component of lipid rafts involved in TCR signal transduction, physiological functions of sphingomyelin, overview Homo sapiens ?
-
 ?
2.7.8.27 phosphatidylcholine + C6-NBD-ceramide i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Homo sapiens
2.7.8.27 sphingomyelin synthase 1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.27 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.27 7.4
-
 assay at Homo sapiens