BRENDA - Enzyme Database show

Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models

Mercader, J.; Granados, N.; Caimari, A.; Oliver, P.; Bonet, M.L.; Palou, A.; Horm. Metab. Res. 40, 467-472 (2008)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate
Rattus norvegicus
-
nicotinamide mononucleotide + inorganic diphosphate
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Rattus norvegicus
Q80Z29
male Wistar rats, six-months-old, develop diet-induced hyperphagia and obesity, male obese (fa/fa) Zucker rats, three-months-old, display genetic obesity due to deficit in leptin receptors, and male lean Zucker rats, three-month-old
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
blood serum
similar mRNA expression levels in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) as well as in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
Rattus norvegicus
-
2.4.2.12
groin
inguinal white adipose tissue
Rattus norvegicus
-
2.4.2.12
visceral fat
similar mRNA expression levels in mesenteric, retroperitoneal and epididymal WAT depots of (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control)
Rattus norvegicus
-
2.4.2.12
white adipose tissue
lean Wistar rats: mRNA expression levels are maximal in mesenteric WAT (2.01 +/-0.08) followed by inguinal (1.23 +/-0.15), epididymal (0.88 +/-0.13), and retroperitoneal (0.79 +/-0.07) WAT; lean Zucker rats: mRNA expression levels are similar in subcutaneous (inguinal, 1.18 +/-0.33) and visceral (mesenteric (0.99 +/-0.15), retroperitoneal (0.56 +/-0.10), epididymal (1.17 +/-0.14)) WAT; mesenteric, significantly decreased mRNA expression level in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control); significantly reduced mRNA expression level in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) and in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate
-
692570
Rattus norvegicus
nicotinamide mononucleotide + inorganic diphosphate
-
-
-
r
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate
Rattus norvegicus
-
nicotinamide mononucleotide + inorganic diphosphate
-
-
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
blood serum
similar mRNA expression levels in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) as well as in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
Rattus norvegicus
-
2.4.2.12
groin
inguinal white adipose tissue
Rattus norvegicus
-
2.4.2.12
visceral fat
similar mRNA expression levels in mesenteric, retroperitoneal and epididymal WAT depots of (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control)
Rattus norvegicus
-
2.4.2.12
white adipose tissue
lean Wistar rats: mRNA expression levels are maximal in mesenteric WAT (2.01 +/-0.08) followed by inguinal (1.23 +/-0.15), epididymal (0.88 +/-0.13), and retroperitoneal (0.79 +/-0.07) WAT; lean Zucker rats: mRNA expression levels are similar in subcutaneous (inguinal, 1.18 +/-0.33) and visceral (mesenteric (0.99 +/-0.15), retroperitoneal (0.56 +/-0.10), epididymal (1.17 +/-0.14)) WAT; mesenteric, significantly decreased mRNA expression level in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control); significantly reduced mRNA expression level in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) and in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + alpha-D-5-phosphoribosyl-1-diphosphate
-
692570
Rattus norvegicus
nicotinamide mononucleotide + inorganic diphosphate
-
-
-
r