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Literature summary extracted from

  • Kiyan, J.; Haller, H.; Dumler, I.
    The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells (2008), Exp. Cell Res., 315, 1029-1039.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.48 UpA uPA regulates SHP-2 phosphorylation, stimulates its catalytic activity and association with PDGFR-beta and with lipid rafts Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.48 cytosol
-
 Homo sapiens 5829
-
3.1.3.48 nucleus SHP-2 can dephosphorylate STAT1 in cell nucleus Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 vascular smooth muscle cell
-
 Homo sapiens
-
3.1.3.48 VSMC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.48 phosphorylated platelet-derived growth factor receptor + H2O
-
 Homo sapiens platelet-derived growth factor receptor + phosphate
-
 ?
3.1.3.48 phosphorylated STAT1 + H2O
-
 Homo sapiens STAT1 + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 PTK
-
 Homo sapiens
3.1.3.48 Scr homology 2-containing tyrosine phosphatase
-
 Homo sapiens
3.1.3.48 SHP-2
-
 Homo sapiens
3.1.3.48 tyrosine phosphatase
-
 Homo sapiens