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Literature summary extracted from

  • Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
    PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries (2008), Eur. J. Pharmacol., 582, 102-109.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.17 cGMP PDE2 is stimulated by cGMP Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 3-isobutyl-1-methylxanthine broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor; broad-spectrum PDE inhibitor Homo sapiens
3.1.4.17 8-methoxymethyl-3-isobutyl-1-methylxanthine 0.02 mM selectively inhibits PDE1; 0.02 mM selectively inhibits PDE1 Homo sapiens
3.1.4.35 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride specific inhibitor of PDE5 Homo sapiens
3.1.4.35 dipyridamole PDE5 is specifically inhibited by dipyridamole Homo sapiens
3.1.4.53 rolipram PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.17 Ca2+ Ca2+ activates Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Homo sapiens O00408 PDE2A
-
3.1.4.17 Homo sapiens P54750 PDE1A
-
3.1.4.17 Homo sapiens Q01064 PDE1B
-
3.1.4.35 Homo sapiens O76074 PDE5A
-
3.1.4.53 Homo sapiens P27815 PDE4A
-
3.1.4.53 Homo sapiens Q07343 PDE4B
-
3.1.4.53 Homo sapiens Q08493 PDE4C
-
3.1.4.53 Homo sapiens Q08499 PDE4D
-
3.1.4.53 Homo sapiens Q13946 PDE7A
-
3.1.4.53 Homo sapiens Q13946 PDE7A2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 umbilical artery smooth muscle
-
 Homo sapiens
-
3.1.4.35 umbilical artery smooth muscle
-
 Homo sapiens
-
3.1.4.53 umbilical artery smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
3.1.4.35 3',5'-cGMP + H2O PDE5 hydrolyses selectively 3',5'-cGMP with high affinity Homo sapiens 5'-GMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O specific substrate Homo sapiens 5'-AMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O PDE4 hydrolyses selectively 3',5'-cAMP with high affinity Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE1
-
 Homo sapiens
3.1.4.17 PDE1A isoform Homo sapiens
3.1.4.17 PDE1B isoform Homo sapiens
3.1.4.17 PDE2
-
 Homo sapiens
3.1.4.17 PDE2A isoform Homo sapiens
3.1.4.35 PDE5 key enzyme involved in the regulation of the smooth muscle relaxation associated to cGMP Homo sapiens
3.1.4.35 PDE5A isoform Homo sapiens
3.1.4.53 PDE4 key enzyme involved in the regulation of the smooth muscle relaxation associated to cAMP Homo sapiens
3.1.4.53 PDE4A isoform Homo sapiens
3.1.4.53 PDE4B isoform Homo sapiens
3.1.4.53 PDE4C isoform Homo sapiens
3.1.4.53 PDE4D isoform Homo sapiens
3.1.4.53 PDE7
-
 Homo sapiens
3.1.4.53 PDE7A isoform Homo sapiens
3.1.4.53 PDE7A2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.4.17 Calmodulin
-
 Homo sapiens