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Literature summary extracted from

  • Foster, P.A.; Woo, L.W.; Potter, B.V.; Reed, M.J.; Purohit, A.
    The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer (2008), Endocrinology, 149, 4035-4042.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 STX64 synonyms BN83495 or 667Coumate, 1 mg/kg/day given orally, treatment starting at Ishikawa cell tumor size of about 100 cubic mm (intact mice): no significant tumor growth reduction after 35 days of inhibitor treatment. Estradiol sulfate stimulated tumor growth of Ishikawa cells in ovariectomized mice, results after day 28 of inhibitor treatment: 1 mg/kg/day given orally reduces tumor growth by 48%, complete Ishikawa cell tumor STS inhibition, 1 mg/kg given orally once weekly: no tumor growth inhibition, no tumor STS inhibition, 10 mg/kg/day given orally: tumor growth inhibition by 59%, complete tumor STS inhibition Homo sapiens
3.1.6.2 STX64 synonyms BN83495 or 667Coumate, estradiol sulfate stimulates tumor growth of Ishikawa cells in ovariectomized mice, results after day 28 of inhibitor treatment: 1 mg/kg/day given orally completely inhibits mouse liver STS acitivity, and reduces plasma estradiol by 63%, 1 mg/kg given orally and once weekly inhibits liver STS activity by about 40%, no plasma estradiol reduction, 10 mg/kg given orally and once weekly: complete inhibition of liver STS, and reduction of plasma estradiol by 93% Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 estrone sulfate + H2O Mus musculus
-
 estrone + sulfate subsequent conversion to estradiol ?
3.1.6.2 estrone sulfate + H2O Homo sapiens
-
 estrone + sulfate subsequent conversion to estradiol ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-
3.1.6.2 Mus musculus
-
 intact, athymic, female MF-1 nude mice (in vivo tumor growth model), ovariectomized, athymic, female MF-1 nude mice (hormone-dependent in vivo tumor growth model)
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 Ishikawa cell human endometrial adenocarcinoma cells transplanted into athymic MF-1 intact and ovariectomized naked mouse model Homo sapiens
-
3.1.6.2 liver MF-1 mice with transplanted Ishikawa cells grown into tumors Mus musculus
-
3.1.6.2 plasma MF-1 mice with transplanted Ishikawa cells grown into tumors Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
 Mus musculus estrone + sulfate subsequent conversion to estradiol ?
3.1.6.2 estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate subsequent conversion to estradiol ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 steroid sulfatase
-
 Mus musculus
3.1.6.2 steroid sulfatase
-
 Homo sapiens
3.1.6.2 STS
-
 Mus musculus
3.1.6.2 STS
-
 Homo sapiens