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Literature summary extracted from

  • Rowland, A.; Knights, K.M.; Mackenzie, P.I.; Miners, J.O.
    The albumin effect and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities (2008), Drug Metab. Dispos., 36, 1056-1062.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 bovine serum albumin activates isozyme UGT1A9 by reducing the Km of the substrates, overview Homo sapiens
2.4.1.17 fatty acid-free human serum albumin activates isozyme UGT1A9 by reducing the Km of the substrates, overview Homo sapiens
2.4.1.17 additional information no activation by human serum albumin Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression of isozymes UGT1A1, UGT1A6, and UGT1A9 in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 long-chain unsaturated fatty acids selective inhibition of some UGT isozymes Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information
-
 Homo sapiens
2.4.1.17 0.0029
-
 4-Methylumbelliferone pH 7.4, 37°C, isozyme UGT1A9 in presence of 2% fatty acid-free human serum albumin Homo sapiens
2.4.1.17 0.0072
-
 propofol pH 7.4, 37°C, isozyme UGT1A9 in presence of 2% fatty acid-free human serum albumin Homo sapiens
2.4.1.17 0.0106
-
 propofol pH 7.4, 37°C, liver microsomes in presence of 2% fatty acid-free human serum albumin Homo sapiens
2.4.1.17 0.0134
-
 4-Methylumbelliferone pH 7.4, 37°C, isozyme UGT1A9 Homo sapiens
2.4.1.17 0.041
-
 propofol pH 7.4, 37°C, isozyme UGT1A9 Homo sapiens
2.4.1.17 0.127
-
 propofol pH 7.4, 37°C, liver microsomes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens O60656 isozymes UGT1A1, UGT1A6, and UGT1A9
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + propofol
-
 Homo sapiens UDP + propofol beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 1A9
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens