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Literature summary extracted from

  • Weinkove, D.; Bastiani, M.; Chessa, T.A.; Joshi, D.; Hauth, L.; Cooke, F.T.; Divecha, N.; Schuske, K.
    Overexpression of PPK-1, the Caenorhabditis elegans type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults (2008), Dev. Biol., 313, 384-397.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.68
-
 Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.68 additional information overexpression of isoform PPK-1 in Caenorhabditis elegans causes an increase in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels in vivo. In developing neurons, PPK-1 overexpression leads to growth cones that become stalled, produce ectopic membrane projections, and branched axons. Once neurons are established, PPK-1 overexpression results in progressive membrane overgrowth and degeneration during adulthood Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 plasma membrane enzyme can localize to the plasma membrane Caenorhabditis elegans 5886
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Caenorhabditis elegans O01759 isoform Ppk-1, type I enzyme
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 nervous system strong expression Caenorhabditis elegans
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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 Caenorhabditis elegans ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
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